San Francisco is -210 on the moneyline at Dallas, with the spread at Dallas +4 and the total at 55.5. DraftKings opened Dallas -1.5 and 52.5, now Dallas +4.5 and 55.5.
The last meeting went to San Francisco, 30-24 at home on October 27, 2024, and the 49ers are 2-0 in the last two head-to-head matchups. San Francisco is 7-1 straight up and 5-3 against the spread this season, and 8-2 straight up and 5-5 against the spread over its last 10, most recently a 38-17 win over Las Vegas. Dallas is 4-5 straight up and 3-5-1 against the spread this season, and 4-6 straight up and 3-6-1 against the spread over its last 10, most recently a 27-23 win at Indianapolis.
The defensive ranks are the most useful angle: San Francisco allows 19.5 points (6th) and 80.9 rushing yards (2nd), while Dallas allows 26.2 points (26th) and 147.4 rushing yards (31st). Dallas lists Jake Ferguson and Jonathan Mingo out and Joey Porter Jr. questionable. Christian McCaffrey’s anytime touchdown prop is -240 after clearing 8 of his last 10.
Hit rate = how often the player cleared this line in recent games. Best price across 30+ sportsbooks, DFS apps and exchanges as of 1:31 PM ET.
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Each player’s lines against what this defense allows to his position this season. The ranks run from the defense allowing the fewest to the one allowing the most. Bars show how often he cleared the line over his recent games, green at 70% or better.
Brock Purdy vs Cowboys
Brock PurdyQB, SF
VS
CowboysDefense vs quarterbacks
Good matchup for Brock PurdyCowboys allow 26.9 rushing yards a game to quarterbacks, 3rd most in the league. Purdy averages 26.2 against a line of 19.5.
Toughest30th of 32, rushing yardsSoftest
Rushing yards over 19.58/10avg 26.2 · 30th of 32 vs QB · -104
Passing tds over 1.57/10avg 1.9 · 23rd of 32 vs QB · -208
Passing yards over 261.55/10avg 238.2 · 16th of 32 vs QB · -110
Christian McCaffrey vs Cowboys
Christian McCaffreyRB, SF
VS
CowboysDefense vs running backs
Good matchup for Christian McCaffreyCowboys allow 112.8 rushing yards a game to running backs, 4th most in the league. McCaffrey averages 54 against a line of 32.5.
Toughest29th of 32, rushing yardsSoftest
Rushing yards over 32.59/10avg 54 · 29th of 32 vs RB · -110
Receptions over 3.57/10avg 4.7 · 16th of 32 vs RB · -167
Rushing tds over 0.57/10avg 0.9 · 27th of 32 vs RB · -161
Keenan Allen vs Cowboys
Keenan AllenWR, SF
VS
CowboysDefense vs wide receivers
Good matchup for Keenan AllenCowboys allow 159.3 receiving yards a game to wide receivers, 10th most in the league. Allen averages 41.2 against a line of 20.5.
Toughest23rd of 32, receiving yardsSoftest
Receiving yards over 20.59/10avg 41.2 · 23rd of 32 vs WR · -109
Receptions over 2.59/10avg 5 · 19th of 32 vs WR · +110
Receiving tds over 0.51/10avg 0.1 · 21st of 32 vs WR · +380
CeeDee Lamb vs 49ers
CeeDee LambWR, DAL
VS
49ersDefense vs wide receivers
Even matchup49ers allow 0.8 receiving touchdowns a game to wide receivers, 11th fewest in the league. Lamb averages 0.7 against a line of 0.5.
Toughest11th of 32, receiving touchdownsSoftest
Receiving tds over 0.55/10avg 0.7 · 11th of 32 vs WR · -101
Receiving yards over 89.54/10avg 90.8 · 6th of 32 vs WR · -104
Receptions over 7.54/10avg 7.1 · 10th of 32 vs WR · +127
Ryan Flournoy vs 49ers
Ryan FlournoyWR, DAL
VS
49ersDefense vs wide receivers
Tough matchup for Ryan Flournoy49ers allow 122.6 receiving yards a game to wide receivers, 6th fewest in the league. Flournoy averages 46.3 against a line of 37.5.
Toughest6th of 32, receiving yardsSoftest
Receiving yards over 37.56/10avg 46.3 · 6th of 32 vs WR · -111
Receptions over 3.55/10avg 3.7 · 10th of 32 vs WR · +107
Receiving tds over 0.52/10avg 0.2 · 11th of 32 vs WR · +250
Javonte Williams vs 49ers
Javonte WilliamsRB, DAL
VS
49ersDefense vs running backs
Tough matchup for Javonte Williams49ers allow 0.3 rushing touchdowns a game to running backs, 2nd fewest in the league. Williams averages 1 against a line of 0.5.
Toughest2nd of 32, rushing touchdownsSoftest
Rushing tds over 0.58/10avg 1 · 2nd of 32 vs RB · -109
Receiving yards over 15.55/10avg 12.7 · 29th of 32 vs RB · +100
Rushing yards over 60.54/10avg 68.3 · 5th of 32 vs RB · -110
Betting trends
The over is 7-3 in Cowboys’ last 10 games.
From each team’s last 10 games and recent meetings, against the closing line.
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49ers vs Cowboys defense vs position
What each defense allows per game this season to everyone listed at a position, combined, so a row covers more than the starter. The small number is the rank across 32 teams: 1st allows the fewest. Green is the softest third of the league, red the toughest.
49ers defense facing the Cowboys
Pos
Pass yds
Rush yds
Rec yds
Catches
TDs
QB
222.99th
5.32nd
–
–
1.410th
RB
–
71.55th
43.629th
6.832nd
0.32nd
WR
–
–
122.66th
10.310th
0.811th
TE
–
–
56.619th
6.526th
0.415th
Softest spot: 6.8 receptions a game to running backs, the most in the league.
Toughest spot: 5.3 rushing yards a game to quarterbacks, 2nd fewest in the league.
Cowboys defense facing the 49ers
Pos
Pass yds
Rush yds
Rec yds
Catches
TDs
QB
237.016th
26.930th
–
–
1.823rd
RB
–
112.829th
27.49th
4.416th
1.027th
WR
–
–
159.323rd
11.719th
1.021st
TE
–
–
50.213th
5.417th
0.416th
Softest spot: 26.9 rushing yards a game to quarterbacks, 3rd most in the league.
Toughest spot: 27.4 receiving yards a game to running backs, 9th fewest in the league.
The props these matchups touchEvery NFL line beside its hit rate and matchup. Free preview of today’s props, more with a free account. Pro unlocks all of it.
Season averages and each player’s last 5 games, newest first. Splits: per-game averages (games in brackets); vs the opponent covers this season and last, newest game first.
This season, regular season. ATS and O/U against each game’s closing line.
49ers vs Cowboys head-to-head
49ers are 2-0 in the last 2 meetings. Last time: 49ers won 30-24 on October 27, 2024.
Date
Venue
49ers result
ATS
O/U
Oct 27, 24
49ers home
W 30-24
–
–
Oct 8, 23
49ers home
W 42-10
–
–
Recent form
San Francisco 49ers: last 10 (8-2, 5-5 ATS, O/U 5-5)
Date
Opponent
Result
ATS
O/U
Nov 8, 26
vs LV
W 38-17
W -8.5
O 51.5
Oct 25, 26
@ ATL
L 20-29
L -2.5
U 49.5
Oct 19, 26
vs WSH
W 23-17
L -7.5
U 51.5
Oct 11, 26
@ SEA
W 32-29
W +3
O 46.5
Oct 4, 26
vs DEN
W 24-14
W -3
U 48.5
Sep 27, 26
vs ARI
W 36-30
L -7.5
O 48.5
Sep 20, 26
vs MIA
W 35-13
W -12.5
O 44.5
Sep 10, 26
@ LAR
W 27-7
W +3.5
U 47.5
Jan 3, 26
vs SEA
L 3-13
L +2.5
U 48.5
Dec 28, 25
vs CHI
W 42-38
L -4.5
O 51.5
Dallas Cowboys: last 10 (4-6, 3-6-1 ATS, O/U 7-3)
Date
Opponent
Result
ATS
O/U
Nov 8, 26
@ IND
W 27-23
L -4.5
U 51.5
Nov 1, 26
vs ARI
L 30-33
L -7
O 54.5
Oct 26, 26
@ PHI
W 38-21
W -4.5
O 43.5
Oct 18, 26
@ GB
L 13-23
L -1.5
U 54.5
Oct 8, 26
vs TB
L 16-24
L -8.5
U 49.5
Oct 4, 26
@ HOU
W 34-30
W +3
O 48.5
Sep 27, 26
vs BAL
L 31-34
P +3
O 54.5
Sep 20, 26
vs WSH
W 37-20
W -4.5
O 51.5
Sep 13, 26
@ NYG
L 20-28
L -3
O 47.5
Jan 4, 26
@ NYG
L 17-34
L -3
O 50.5
Injury report
San Francisco 49ers
Isaac Guerendo (RB): PUP-R, Guerendo
Darrick Forrest (S): IR, San Francisco placed Forrest
Sam Okuayinonu (DT): IR, Okuayinonu broke his foot in practice last week and is set to have surgery to repair the issue, Matt Barrows of The Athletic reports
Nick Zakelj (OT): IR, Zakelj
Alfred Collins (DT): IR, San Francisco placed Collins
De’Zhaun Stribling (WR): IR, Stribling
C.J. West (DT): IR-R, West
Deommodore Lenoir (CB): Questionable, Lenoir
Trent Williams (OT): Questionable, Williams
Dre Greenlaw (LB): Questionable, Greenlaw
Brandon Aiyuk (WR): Out, The 49ers reinstated Aiyuk
Ricky Pearsall (WR): IR, Pearsall announced Thursday in a post on his personal Instagram account that he underwent season-ending surgery to repair the PCL in his right knee, David Lombardi of SFStandard
Andrew Farmer II (DE): IR, San Francisco placed Farmer
Mikail Kamara (DE): IR
Nate Hobbs (CB): IR-R, San Francisco didn’t activate Hobbs
Nick Martin (LB): IR, Head coach Kyle Shanahan said Monday that Martin’s
Austen Pleasants (OT): IR-R, The 49ers placed Pleasants
Jake Tonges (TE): IR, Tonges
Mike Evans (WR): Out, Evans
Christian Kirk (WR): IR, The 49ers placed Kirk
Renardo Green (CB): Questionable, Green
Gracen Halton (DT): IR, The 49ers placed Halton
Upton Stout (CB): Questionable, questionable
Dallas Cowboys
Princeton Fant (TE): IR, ir
Matt Hennessy (C): IR, ir
Devin Moore (CB): IR-R, The Cowboys designated Moore
Malik Davis (RB): IR, The Cowboys placed Davis
Jonathan Bullard (DT): IR-R, Bullard
Joey Porter Jr. (CB): Questionable, Porter
Jake Ferguson (TE): Out, According to coach Brian Schottenheimer, Ferguson
Jonathan Mingo (WR): Out, Mingo
P.J. Locke (S): Out, Locke
Tyler Goodson (RB): Out, Goodson sustained ACL and MCL sprains in his knee during Sunday’s 27-23 win over the Colts, a source tells Todd Archer of ESPN
Alijah Clark (S): Questionable, questionable
DaRon Bland (CB): Questionable, Bland
Kelvin Gilliam Jr. (DT): IR, Gilliam
Jalen Thompson (S): IR, Thompson
Malachi Lawrence (LB): IR, Dallas placed Lawrence
Donovan Ezeiruaku (LB): Out, Ezeiruaku
Juanyeh Thomas (S): Doubtful, doubtful
Matchup ranks
What each defense allows per game this season. Rank 1 allows the fewest, so a high number means a softer matchup for the other team’s overs.
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Highlighted: the best price in each column as of 1:31 PM ET. Prices move; check the book before you bet.
Line movement from the open
Line
Open
Now
Move
Cowboys spread
-1.5
+4.5
+6
Total
52.5
55.5
+3
49ers moneyline
+100
-218
+18.6% win chance
Cowboys moneyline
-120
+180
-18.8% win chance
DraftKings opening and current numbers via ESPN.
Line movement chart
Cowboys spread +4 → +4.5Total 55.5 → 55.5
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Circa
Hard Rock
Kalshi
Heritage
Brock PurdyQB, SF
Christian McCaffreyRB, SF
Keenan AllenWR, SF
CeeDee LambWR, DAL
Ryan FlournoyWR, DAL
Javonte WilliamsRB, DAL
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