| Team | Moneyline | Spread | Total |
|---|---|---|---|
| San Francisco 49ers |
-144  |
-2.5 -115  |
O 49.5 -110 |
| Atlanta Falcons |
+125  |
+2.5 +100 |
U 49.5 -106  |
Best price at bet365, BetRivers, Caesars, DraftKings, FanDuel and Fanatics, updated 7:13 AM ET.
49ers vs Falcons preview
San Francisco is the favorite at -144 on the moneyline, Atlanta is +2.5 on the spread, and the total is 49.5. The last meeting was Oct. 19, 2025, when San Francisco won 20-10 at home. The 49ers are 6-0 and 4-2 against the spread this season, 9-1 and 6-4 ATS over their last 10, and most recently beat Washington 23-17. Atlanta is 2-4 and 2-4 ATS this season, 6-4 and 5-5 ATS over its last 10, and most recently lost 31-23 to Chicago.
The defensive ranks offer the clearest split: San Francisco allows 18.3 points per game (fourth), while Atlanta allows 268.7 passing yards per game (29th). Atlanta also has Brian Robinson Jr. out and Olamide Zaccheaus questionable; San Francisco lists Christian Kirk and Upton Stout as questionable. On the prop side, Brock Purdy’s over 19.5 rushing yards at -108 has cleared in 9 of his last 10.
Top 49ers vs Falcons player props
| Player | Prop | Best price | Last 10 | Last 5 |
|---|---|---|---|---|
| Brock Purdy SF | Over 19.5 rushing yards | -108  Kalshi |
90% (9/10) | 80% |
| Austin Hooper ATL | Over 4.5 receiving yards | -110  Hard Rock |
90% (9/10) | 100% |
| Zachariah Branch ATL | Over 5.5 receiving yards | -112  prophetexchange |
83.3% (5/6) | 100% |
| Eddy Pineiro SF | Over 2.5 xp made | -115  ESPN BET |
80% (8/10) | 80% |
| Kyle Juszczyk SF | Over 9.5 longest reception | -109 DraftKings |
70% (7/10) | 100% |
Hit rate = how often the player cleared this line in recent games. Best price across 30+ sportsbooks, DFS apps and exchanges as of 7:13 AM ET. See every prop for this game on StatsBench.
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49ers vs Falcons odds by sportsbook
| Book | SF spread | ATL spread | SF ML | ATL ML | Over | Under |
|---|---|---|---|---|---|---|
 bet365 |
-2.5 -118 | +2.5 -102 | -148 | +124 | O 49.5 -111 | U 49.5 -109 |
| BetRivers |
-3 -104 | +3 -116 | -147 | +120 | O 49.5 -114 | U 49.5 -106 |
| Caesars |
-2.5 -120 | +2.5 +100 | -148 | +125 | O 49.5 -114 | U 49.5 -106 |
| DraftKings |
-2.5 -115 | +2.5 -105 | -148 | +124 | O 49.5 -110 | U 49.5 -110 |
| FanDuel |
-2.5 -118 | +2.5 -104 | -144 | +122 | O 49.5 -110 | U 49.5 -110 |
 Fanatics |
-2.5 -120 | +2.5 +100 | -150 | +125 | O 49.5 -110 | U 49.5 -110 |
Highlighted: the best price in each column as of 7:13 AM ET. Prices move; check the book before you bet.
Line movement since we first listed this game (Sat 7:13 AM ET): no change in the main lines yet.
Records
| Team | Record | ATS | O/U | Home | Away |
|---|---|---|---|---|---|
| 49ers |
6-0 | 4-2 | 3-3 | 4-0 | 2-0 |
| Falcons |
2-4 | 2-4 | 4-2 | 0-3 | 2-1 |
This season, regular season. ATS and O/U against each game’s closing line.
49ers vs Falcons head-to-head
49ers are 1-0 in the last 1 meeting. Last time: 49ers won 20-10 on October 19, 2025.
| Date | Venue | 49ers result | ATS | O/U |
|---|---|---|---|---|
| Oct 19, 25 | 49ers home | W 20-10 | – | – |
Recent form
San Francisco 49ers: last 10 (9-1, 6-4 ATS, O/U 6-4)
| Date | Opponent | Result | ATS | O/U |
|---|---|---|---|---|
| Oct 19, 26 | vs WSH | W 23-17 | L -7.5 | U 51.5 |
| Oct 11, 26 | @ SEA | W 32-29 | W +3 | O 46.5 |
| Oct 4, 26 | vs DEN | W 24-14 | W -3 | U 48.5 |
| Sep 27, 26 | vs ARI | W 36-30 | L -7.5 | O 48.5 |
| Sep 20, 26 | vs MIA | W 35-13 | W -12.5 | O 44.5 |
| Sep 10, 26 | @ LAR | W 27-7 | W +3.5 | U 47.5 |
| Jan 3, 26 | vs SEA | L 3-13 | L +2.5 | U 48.5 |
| Dec 28, 25 | vs CHI | W 42-38 | L -4.5 | O 51.5 |
| Dec 22, 25 | @ IND | W 48-27 | W -4.5 | O 46.5 |
| Dec 14, 25 | vs TEN | W 37-24 | W -12.5 | O 44.5 |
Atlanta Falcons: last 10 (6-4, 5-5 ATS, O/U 6-4)
| Date | Opponent | Result | ATS | O/U |
|---|---|---|---|---|
| Oct 18, 26 | vs CHI | L 23-31 | L +1.5 | O 50.5 |
| Oct 11, 26 | vs BAL | L 23-30 | L -3 | O 44.5 |
| Oct 5, 26 | @ NO | W 45-24 | W +1.5 | O 48.5 |
| Sep 24, 26 | @ GB | W 35-14 | W +4.5 | O 43.5 |
| Sep 20, 26 | vs CAR | L 3-34 | L +2.5 | U 43.5 |
| Sep 13, 26 | @ PIT | L 13-20 | L +6.5 | U 40.5 |
| Jan 4, 26 | vs NO | W 19-17 | L -3.5 | U 43.5 |
| Dec 29, 25 | vs LAR | W 27-24 | W +7.5 | O 48.5 |
| Dec 21, 25 | @ ARI | W 26-19 | W -2.5 | U 48.5 |
| Dec 11, 25 | @ TB | W 29-28 | W +6 | O 43.5 |
Injury report
San Francisco 49ers
- Christian Kirk (WR): questionable
- Upton Stout (CB): questionable
Atlanta Falcons
- Brian Robinson Jr. (RB): out
- Olamide Zaccheaus (WR): questionable
Matchup ranks
What each defense allows per game this season. Rank 1 allows the fewest, so a high number means a softer matchup for the other team’s overs.
| 49ers defense | Falcons defense | |
|---|---|---|
| Points allowed per game | 18.3 (4th of 32) | 25.5 (23rd of 32) |
| Passing yards allowed per game | 225.7 (11th of 32) | 268.7 (29th of 32) |
| Rushing yards allowed per game | 90.2 (8th of 32) | 83.2 (4th of 32) |
| Receptions allowed per game | 23.5 (26th of 32) | 26.5 (31st of 32) |
StatsBench picks
No StatsBench pick posted for this game. Today’s posted picks are graded live.
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